FIGURE 6.

T cells infiltrating the CNS are not predictive of HIV DNA levels in the brain. (A) Correlative analysis of frequency of infiltrating CD3+ T cells (as measured by immunohistochemistry) and HIV pol DNA levels (as determined by droplet digital PCR) in frontal brain tissue from virally suppressed (n = 10) or viremic PWH (n = 10; groups combined are shown; n = 20). (B) Correlative analysis of relative expression of TCR mRNA and HIV pol DNA levels from fresh frozen human brain of PWH (n = 11). Parameters log transformed and spearman rho and p value shown. p < 0.05 considered statistically significant. CNS = central nervous system; PCR = polymerase chain reaction; PWH = people with HIV; TCR = T cell receptor.