Table 1.
Genotypic profiles of four drivers in different PDAC cell lines
| Gene name | Genotype | Cell line name | Exon | Mutation location |
|---|---|---|---|---|
| KRAS | WT | Bxpc-3 | ||
| Panc0403 | ||||
| Mut | Su86.86 | exon 2 | G12D | |
| PANC-1 | G12D | |||
| Aspc-1 | G12D | |||
| CF-PANC1 | G12V | |||
| MIA PaCa-2 | G12C | |||
| HupT-3 | G12R | |||
| TP53 | WT | Aspc-1 | ||
| Panc0403 | ||||
| Mut | Su86.86 | exon 6, 9, 10 | G201V,G228V,G321V,G360V,G602,G683T,G962T,G1079T | |
| PANC-1 | exon 4, 7, 8 | R114H,R141H,R234H,R273H,G341A,G422A,G701A,G818A | ||
| CF-PANC1 | exon 3, 6, 7 | C83R,C110R,C203R,C242R,T247C,T328C,T607C,T724C | ||
| MIA PaCa-2 | exon 3, 6, 7 | R89W,R116W,R209W,R248W,C265T,C346T,C625T,C742T | ||
| HupT-3 | exon 4, 8 | R123W,R150W,R243W,R282W,C367T,C448,C727T,C844T | ||
| Bxpc-3 | exon 2, 5, 6 | Y61C,Y88C,Y181C,A182G,Y220C,A263G,A542G,A659G | ||
| CDKN2A | WT | Su86.86 | ||
| Bxpc-3 | ||||
| PANC-1 | ||||
| Aspc-1 | ||||
| CF-PANC1 | ||||
| MIA PaCa-2 | ||||
| HupT-3 | ||||
| Mut | PAN0403 | exon 2 | R99C,R96G,R90C,S73R | |
| SMAD4 | WT | Su86.86 | ||
| PANC-1 | ||||
| CF-PANC1 | ||||
| Panc0403 | ||||
| MIA PaCa-2 | ||||
| HupT-3 | ||||
| Mut | Aspc-1 | exon 3 | R100T | |
| Bxpc-3 | exon 5, 9 | T496C,F166L; Del,Chr18:48584501-48584728:51-178 |
WT wild type, Mut mutation.