Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 20;13:5512. doi: 10.1038/s41467-022-33252-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — A Histogram of the size distribution for PD (burgundy, N = 54218) and control brain-derived aggregates (beige, N = 48222). Each histogram is the collected data from three cases. B Difference between the histograms for size distribution. C Cumulative frequency distribution for aggregate length for PD and controls. Each histogram is the collected data from three cases (Kolmogorov-Smirnov test, p < 0.001 for PD versus controls). D Difference between the cumulative frequencies for the size distribution. E Boxplot comparing aggregate length in PD versus controls. Box limits represent minimum and maximum value, horizontal line in the centre indicating median (Mann–Whitney U test, p < 0.001). F Scatter plot of the mean eccentricity of all aggregates with each point representing the mean value of three patients per group (two-tailed unpaired t-test, p = 0.909, N = 3 for PD and controls). G SR representative images for PD cases showing the corresponding aggregate size and eccentricity. H SR representatives for controls showing the corresponding aggregate size and eccentricity. The LUT Fire has been applied to all images. Scale bar = 500 nm. Source data are provided as a Source Data file. PD = Parkinson’s disease patients vs HC = control patients.