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. 2022 Sep 7;15:974480. doi: 10.3389/fnmol.2022.974480

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Copyright © 2022 Wang, Yang, He, Pu, Yang, Wu, Zhou, Cen and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic overview of mitochondrial ion channels that are implicated in neurodegeneration. Mitochondrial ion channels are a group of integral membrane proteins mediating ionic fluxes across the mitochondrial membranes. VDAC is a voltage-dependent anion channel residing in the OMM and MCU is a mitochondrial calcium uniporter in the IMM. PTP is a mitochondrial permeability transition pore that allows mitochondria to undergo a sudden increase of permeability, including VDAC in the OMM and the adenine nucleotide translocase (ANT) in the IMM. Cyclophilin D (CypD) in the matrix is a sensitizer of PTP. Peripheral benzodiazepine receptor (BPR), hexokinase (HK), and creatine kinase (CK) are the other components of PTP.