Table 1.
Clinicopathological characteristics of patients with small HCC and their differences between distant metastasis and non-distant metastasis groups.
| Variable | Total cohort (n = 4176) | Non-metastasis (n = 4033) | Metastasis (n = 143) | P value |
|---|---|---|---|---|
| Age, mean ± SD, year | 63.6 ± 9.9 | 63.6 ± 9.8 | 63.5 ± 12.0 | 0.944 |
| Gender, n (%) | ||||
| Male | 3084 (73.9) | 2970 (73.6) | 114 (79.7) | 0.104 |
| Female | 1092 (26.1) | 1063 (26.4) | 29 (20.3) | |
| Race, n (%) | ||||
| Black | 568 (13.6) | 542 (13.4) | 28 (19.6) | 0.059 |
| White | 2822 (67.6) | 2727 (67.6) | 95 (66.4) | |
| Others* | 784 (18.8) | 764 (18.9) | 20 (14.0) | |
| Marital status, n (%) | ||||
| Married | 2414(57.8) | 2346 (58.2) | 68 (47.6) | 0.012 |
| Unmarried | 1762(42.2) | 1687 (41.8) | 75 (52.4) | |
| Tumor size, mean ± SD, mm | 30.5 ± 10.9 | 30.4 ± 10.9 | 33.9 ± 12.2 | < 0.001 |
| Histological grade, n (%) | ||||
| I | 1421 (34.0) | 1382 (34.3) | 39 (27.3) | < 0.001 |
| II | 2084 (49.9) | 2036 (50.5) | 48 (33.6) | |
| III + IV | 671 (16.1) | 615 (15.2) | 56 (39.2) | |
| T stage, n (%) | ||||
| T1 | 2483(59.5) | 2436 (60.4) | 47 (32.9) | < 0.001 |
| T2 | 1693(40.5) | 1597 (39.6) | 96 (67.1) | |
| N stage, n (%) | ||||
| N0 | 4068 (97.4) | 3964 (98.3) | 104 (72.7) | < 0.001 |
| N1 | 108 (2.6) | 69 (1.7) | 39 (27.3) | |
| AFP, n (%) | ||||
| Negative | 1602 (38.4) | 1570 (38.9) | 32 (22.4) | < 0.001 |
| Positive | 2574 (61.6) | 2463 (61.1) | 111 (77.6) | |
| Fibrosis score, n (%) | ||||
| F0 (0–4) | 385 (9.2) | 374 (9.3) | 11 (7.7) | 0.001 |
| F1 (5–6) | 1379 (33.0) | 1351 (33.5) | 28 (19.6) | |
| Unknown | 2412 (57.8) | 2308 (57.2) | 104 (72.7) | |
Significant values are in bold.
*The others comprise American Indian/Alaska Native, Asian/Pacific Islander. AFP alpha-fetoprotein, HCC hepatocellular carcinoma.