Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 7;10:967482. doi: 10.3389/fcell.2022.967482

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Saraswat, Przybyla, Joenvaara, Tohmola, Strandin, Puhka, Jouppila, Lassila and Renkonen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Activity measurement of factor Xa and activated protein C shows variable but definite activity among individual samples. (A) Dot plot showing Factor Xa activity (with SD of triplicates) in various samples. PLPBS (Plasma diluted with PBS to same volume as EVs). PLP18 (Plasma diluted with P18 5:4 at P18 concentration of 50 µg/m). PLP200 (Plasma diluted with P200, 5:4 at P200 concentration of 50 µg/ml). PLPPPLow and PLPRP (diluted plasma with the PPPLow reagent and the PRP reagent at 4:1). P18 (Microvesicles without any addition), P200 (Exosomes without any addition), P18PPPLow and P18PRP (P18 supplemented with the PPPLow and the PRP reagent, respectively at 4:1). P200PPPLow and P200PRP (P200 supplemented with the PPPLow and the PRP reagent, respectively at 4:1). (B) Activated protein C (APC) activity in P18 (Microvesicles) per 1mg of total protein from 8 donors (P18-1 to P18-8), and the APC activity in P200 (Exosomes) per 1mg of total protein from 8 donors (P200-1 to P200-8), using the fluorescent substrate-based assay.