Table 1.

Studies depicting various conditions and effects with application of BFRT

Study aim	Author	Year	Participants	Findings	Conclusion
To induce strength gain and hypertrophy in combination of BFR and low-load (LL) exercises.	Natsume et al [14]	2015	Untrained young males (n = 8)	Increase in muscle thickness (+3.9%) after 2 weeks of training. There is a maximal knee extension strength isometric (+14.2%), isokinetic (+7.0%) at voluntary contraction.	NMES in combination with BFR results in an increase in muscle hypertrophy.
To determine the progress in muscle strength with moderate BFR and LL training in ACL reconstruction.	Ohta et al [9]	2003	Patients post-ACL reconstruction surgery trained with BFR (n = 22) Control group (n = 22)	Significant increase.	Low-load resistance training with moderate BFR during early days of rehabilitation promotes muscle strength and hypertrophy.
To identify the change in Cross-Sectional Area (CSA) of knee extensors following disuse atrophy after ACL reconstruction surgery.	Takarada et al [11]	2000	Patients with ACL reconstruction (n = 8)	Post-occlusion there was 9.4 ± 1.6% and 9.2 ± 2.6% increase in the CSA.	Occlusion of the proximal thigh helps to regain knee extensor strength and function. There was a significant increase in the cross-sectional area of the muscle.
To determine the role of BFR on the Quadriceps muscle strength on elderly patients with knee Osteoarthritis (OA).	Segal et al [10]	2015	Patients with knee OA (n = 22) Control group (n = 22)	There was increase in leg press.	There was no significant increase in knee extensor strength for elderly patients.
To compare the strength of quadriceps muscle with and without BFR training on patella-femoral pain.	Giles et al [15]	2017	Patients trained with BFR (n = 35) Without BFR (n = 34)	There was a significant decrease in pain of about 93% with application of BFRT.	BFRT produced more improvement in pain and contributed in quadriceps strength.