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. 2022 Jul 19;14(5):983–1001. doi: 10.1016/j.jcmgh.2022.07.010

Figure 13.

Figure 13

Hepatic leptin signaling has no effect on the AKT or ERK pathway. (A) Phosphorylation levels of AKT and ERK in 80 ng/mL leptin or vehicle-treated primary hepatocytes. (B) Phosphorylation levels of AKT and ERK in AdGFP- or AdObrb-infected primary hepatocytes in the presence of 80 ng/mL leptin. (C) Phosphorylation levels of AKT and ERK in Obrb knock-down primary hepatocytes in the presence of 80 ng/mL leptin. (D) Phosphorylation levels of AKT and ERK in the liver of AdObrb- or AdGFP-infected mice. Results for cell studies represent 1 of 3 independently performed experiments. pAKT, phospho-AKT; pERK, phospho-ERK1/2.