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. 2022 Sep 6;25(10):105075. doi: 10.1016/j.isci.2022.105075

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The expression and survival analysis of eRNA-mediated immune checkpoint score

(A–C) The immune checkpoints score of three types of gene sets, including major histocompatibility complex (MHC), immune co-inhibitory checkpoints (IAP), and immune co-stimulator checkpoints (ICP), were all significant differences in the three eRNA subtypes (p < 0.05).

(D) The correlation of BTLA and ENSR00000305509 (p < 0.05).

(E) The correlation of TMIGD2 and ENSR00000106294 (p < 0.05).

(F) K-M analysis of the high versus low TMIGD2 expression group in the TCGA GC cohort. (p = 0.0054).

(G) K-M analysis of the high versus low BTLA expression group in the TCGA GC cohort. (p = 0.2).

(H) ENSR00000305509 corresponding mutation driver genes (SYNE1, APC, TP53) (p<0.05).

(I) ENSR00000106294 corresponding mutation driver genes (SYNE1, GPR98, TP53, TNN) (p<0.05).

(J) The correlation of ENSR00000106294 and immunotherapy-related pathway (left). The correlation of ENSR00000305509 and immunotherapy-related pathway (right).