Figure 8.
Predicted eRNA score associated with immunotherapy response and outcomes in GC
(A) The correlation of 28 immune cell types and eRNA score (p < 0.05).
(B) The correlation of effector memory CD4 T cell and eRNA score (p < 0.001).
(C) The correlation of mast cell and eRNA score (p < 0.001).
(D) The boxplot showed a statistical difference in IPS between high- and low-eRNA-score groups (p = 3.2 × 10−7).
(E) The proportion of immunotherapy response rate between three eRNA subtypes by TIDE (Fisher test, p < 0.001).
(F) Kaplan-Meier analysis of the high- versus low-eRNA-score subgroup in the meta-melanoma cohort (p<0.0001).
(G) The proportion of immune response to immunotherapy in high- versus low-eRNA-score subgroups. CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; False, no response; True, response (p=0.082).