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. 2022 Sep 7;14:977411. doi: 10.3389/fnagi.2022.977411

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Copyright © 2022 Mumtaz, Ayaz, Khan, Manzoor, Ganayee, Bhat, Dar, Alghamdi, Hashem, Dar, Ashraf and Maqbool.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ubiquitination in Alzheimer’s disease. Ubiquitination of APP by E3 ligase (Stub1) targets it to endosomal degradation. Mutations at lysine residues inhibit the ubiquitination and endosomal degradation of APP increasing the amyloid burden.