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SUMOylation of BACE1 and HDAC. SUMOylation at Lys 501 enhances the activity of BACE1 which enhances APP cleavage and increases amyloid burden. Any mutation in the BACE 1 SUMOylation site decreases the amyloid burden. SUMOylation of HDAC at Lys 444 and Lys 476 also decreases the amyloid burden.
