TABLE 3.

Ion channels involved in tuning cell behavior in response to physical cues.

Ion channel	Physical cue	Roles
Piezo1	Confinement (Hung et al., 2016)	Cell motility (Yang et al., 2014; Hung et al., 2016; Zhang et al., 2018; Han et al., 2019)
	Mechanical perturbations (Coste et al., 2012; Ranade et al., 2015; Woo et al., 2015; Cox et al., 2016)	Cell proliferation (Zhang et al., 2018; Han et al., 2019; Sun et al., 2020; Hasegawa et al., 2021; Wang et al., 2021)
	Voltage (Moroni et al., 2018)	Invasion (McHugh et al., 2012; Li et al., 2015; Etem et al., 2018; Huang et al., 2019; Yu et al., 2021)
Piezo2	Narrow pores (Pardo-Pastor et al., 2018)	Cell proliferation (Yang et al., 2016; Etem et al., 2018)
	Mechanical perturbations (Coste et al., 2012; Ranade et al., 2015; Woo et al., 2015; Cox et al., 2016)	Invasion (McHugh et al., 2012; Yang et al., 2016; Jiang et al., 2017; Etem et al., 2018; Pardo-Pastor et al., 2018; Huang et al., 2019)
	Voltage (Moroni et al., 2018)	Cell motility (McHugh et al., 2012; Yang et al., 2016; Etem et al., 2018; Pardo-Pastor et al., 2018; Huang et al., 2019)
TRPC1	Pressure (Li et al., 2019c)	Cell proliferation (El Hiani et al., 2009; Sobradillo et al., 2014; Faouzi et al., 2016; Zhang et al., 2020; Sun et al., 2021)
		Cell motility (Fabian et al., 2008; Dong et al., 2010; Zhang et al., 2020; Sun et al., 2021)
		Invasion (He et al., 2012; Sobradillo et al., 2014)
TRPM2	Oxidative stress (Perraud et al., 2005; Huang et al., 2018)	Cell motility (Li et al., 2016; Lin et al., 2018; Almasi et al., 2019; Lin et al., 2021)
		Cell proliferation (Almasi et al., 2018; Lin et al., 2018; Lin et al., 2021)
		Invasion (Lin et al., 2018; Almasi et al., 2019; Lin et al., 2021)
TRPM4	Membrane stretch (Morita et al., 2007)	Cell proliferation (Kappel et al., 2019)
		Cell motility (Cáceres et al., 2015; Kappel et al., 2019; Sagredo et al., 2019)
		Invasion (Cáceres et al., 2015; Kappel et al., 2019; Sagredo et al., 2019)
TRPM7	Shear stress (Yankaskas et al., 2021) Hydraulic resistance (Zhao et al., 2019; Zhao et al., 2021)	Intravasation (Yankaskas et al., 2021)
		Track choice during cell migration (Zhao et al., 2019) and morphology (Zhao et al., 2021)
		Cell proliferation (Sun et al., 2014a; Wang et al., 2014; Gao et al., 2017; Liu et al., 2019b; Su et al., 2019)
		Cell motility (Chen et al., 2010; Middelbeek et al., 2012; Meng et al., 2013; Sun et al., 2014a; Wang et al., 2014; Gao et al., 2017; Liu et al., 2019b; Su et al., 2019; Yang et al., 2020a; Lefebvre et al., 2020)
		Invasion (Meng et al., 2013; Wang et al., 2014; Gao et al., 2017; Liu et al., 2019b; Su et al., 2019; Yang et al., 2020a)
		Apoptosis (Su et al., 2019)
TRPV2	Membrane stretch (Mihara et al., 2010; Shibasaki et al., 2010)	Cell proliferation (Kudou et al., 2019)
		Cell motility (Liu and Wang, 2013; Kudou et al., 2019; Kato et al., 2022)
		Invasion (Liu and Wang, 2013; Kudou et al., 2019; Kato et al., 2022)
		Apoptosis (Kudou et al., 2019)
TRPV4	Stiffness (Adapala et al., 2016; Cappelli et al., 2019; Sharma et al., 2019)	Cell motility (Mrkonjić et al., 2015; Lee et al., 2017a; Ou-Yang et al., 2018; Li et al., 2020c; Zhang et al., 2021)
		Invasion (Ou-Yang et al., 2018; Yang et al., 2020b; Zhang et al., 2021)
		Extravasation (Lee et al., 2016)