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Effect of exposed and unsatisfied polar groups on macrocycle permeability, related to Figures 1 and 3
Designs with exposed polar NH or OH groups in the X-ray crystal structures (orange sticks) are not permeable or show low permeability in PAMPA. Dashed black lines denote the intramolecular hydrogen bonds. The exposed NH or OH groups are denoted by the arrows.
See Data S2 and S3 for design models, structures, and permeability data.
