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. 2022 Sep 7;9:845918. doi: 10.3389/fmed.2022.845918

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Copyright © 2022 Tripska, Igreja Sá, Vasinova, Vicen, Havelek, Eissazadeh, Svobodova, Vitverova, Theuer, Bernabeu and Nachtigal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of TRC105 on hyperglycemia-induced mRNA and protein expression of Eng, and on the Eng transcription factors KLF6, NR1H3, and RELA in HAoECs. (A) Eng mRNA expression. (B) Eng protein levels. (C) KLF6 mRNA expression. (D) NR1H3 mRNA expression. (E) RELA mRNA expression. (F) NF-κB p65 protein levels. For the detailed experimental design, please see Figure 1. The data are presented as mean ± S.E.M (n = 6). ns, p ≥ 0.05; *p < 0.05; **p < 0.01; ***p < 0.001, using Kruskal–Wallis test for comparisons between control, TRC, and HG, and ^†p < 0.05; ^†††p < 0.001, using Mann–Whitney test for comparison between HG vs. TRC/HG.