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. 2022 Sep 21;12(9):220179. doi: 10.1098/rsob.220179

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© 2022 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 1. — Characterization of AASS and the isolated LOR domain. (a) AASS reaction schema with the LOR and SDH activities. (b) Stable AASS expression in HEK-293 Flp-In cells and its inhibition by saccharopine. 10 mM 2-oxoglutarate (OG) was used as substrate. ***, p < 0.001; ****, p < 0.0001. Error bars indicate s.d. (c) Progress curves showing catalytic activity of a short (amino acids 21–451) and long LOR construct (amino acids 21–470), with 1 mM OG, measured in triplicate. Only the average absorption at 340 nm is displayed.