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. 2022 Aug 21;71(8):1735–1745. doi: 10.2337/db21-1069

Figure 1.

Figure 1

Anti–Langerin-fluorophore conjugate demonstrates feasibility and duration of approach. A: Representative flow plot and quantification of thymic Langerin-positive DC frequency in 2-day-old NOD neonates (n = 9). B: In vivo targeting of thymic Langerin-positive DCs by anti-Langerin antibody conjugated to the fluorophore APC. NOD neonates (2 days old) of both sexes were given 3 μg of anti-Langerin antibody conjugated to the fluorophore APC. Thymi were harvested at 24, 48, and 72 hours posttreatment. Data were pooled from three independent experiments; gated on MHCII+CD11c+; Ctrl = untreated; n = 5–7 per group). Data are mean ± SD. Mann-Whitney U test. **P < 0.01.