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. 2022 Sep 7;13:990299. doi: 10.3389/fendo.2022.990299

Figure 2.

Figure 2

Kaempferol reduces SREBPlc to inhibits lipogenesis. Hyperinsulinemia over activates Akt the downstream signaling targets of insulin. Therefore, it causes the activation of AKT/mTORC1/SREBP1C signal and lipogenesis. Kaempferol inhibits the activation of Akt and mTORC1, thereby blocking the activation of the downstream signal SREBP1C. In addition, kaempferol directly activates AMPK to inhibit SREBP1C mediated adipogenesis. IRS, Insulin receptor substrate; PI3K, inosine phosphate 3-kinase; AKT; threonine protein kinase; mTORCl: rapamycin complex 1; S6K, ribosomal protein S6 kinase; INSIG: insulin induced target gene protein; GSK3β, Glycogen synthesis kinase 3β; TSC, tuberous sclerosis; SREBP1, sterol regulatory element binding proteinsl; SCAP, SREBP cleavage-activating protein; FBXW7, F-box and WD repeat domain containing 7; AMPK, AMP-activated protein kinase.