Figure 1.

Cardiac damage in diabetes is associated with higher ROS production. A–C: Light microscopy images show representative 3,3′-diaminobenzidine tetrahydrochloride staining of LV samples obtained from patients with T2DM and NDM. The respective bar graphs show (in brown) the percentage of 8-OH-dG–positive nuclei (A), 3-NT–positive cells (B), and the 4-HNE arbitrary unit (A.U.) intensity levels (C) in T2DM compared with NDM heart tissue cross sections (n = 10 and 6, respectively). Scale bars = 200 μm. Data are mean ± SD.