The width of the connecting line was positively correlated with the patient-years of direct evidence. Different colors of connecting lines corresponded to different outcomes. ACE indicates angiotensin-converting enzyme; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor-neprilysin inhibitor; ASI, angiotensin system inhibitor (ACE inhibitor or ARB); HF, heart failure; MRA, mineralocorticoid receptor antagonist; and SGLT2, sodium-glucose cotransporter 2.