Table 1.
Cohort characteristics
| NI cohort | NI, no GERD | NI+GERD | P value | |
| n (%) | 10 309 | 7537 | 2772 | |
| Age at NI (mean (SD)) | 4.15 (5.82) | 4.65 (6.07) | 2.79 (4.84) | <0.001 |
| Gender (F) | 4738 (46.0) | 3483 (46.2) | 1255 (45.3) | 0.578 |
| CCC | ||||
| Cardiovascular | 1589 (15.4) | 951 (12.6) | 638 (23.0) | <0.001 |
| Metabolic | 743 (7.2) | 429 (5.7) | 314 (11.3) | <0.001 |
| Renal/urologic | 665 (6.5) | 398 (5.3) | 267 (9.6) | <0.001 |
| Genetic/congenital | 2656 (25.8) | 1787 (23.7) | 869 (31.3) | <0.001 |
| Neonatal | 1678 (16.3) | 1200 (15.9) | 478 (17.2) | 0.114 |
| Gastrointestinal | 663 (6.4) | 381 (5.1) | 282 (10.2) | <0.001 |
| Haemat/immunol | 444 (4.3) | 226 (3.0) | 218 (7.9) | <0.001 |
| Respiratory | 485 (4.7) | 182 (2.4) | 303 (10.9) | <0.001 |
| Malignancy | 603 (5.8) | 391 (5.2) | 212 (7.6) | <0.001 |
| No of CCC | <0.001 | |||
| 0 | 4323 (41.9) | 3488 (46.3) | 835 (30.1) | |
| 1 | 3651 (35.4) | 2697 (35.8) | 954 (34.4) | |
| 2 | 1509 (14.6) | 957 (12.7) | 552 (19.9) | |
| 3 | 547 (5.3) | 279 (3.7) | 268 (9.7) | |
| 4+ | 279 (2.7) | 116 (1.5) | 163 (5.9) | |
| Technology | ||||
| Tracheostomy | 75 (0.7) | 28 (0.4) | 47 (1.7) | <0.001 |
| Evacuation tube | 467 (4.5) | 325 (4.3) | 142 (5.1) | 0.089 |
| Gastrostomy | 1359 (13.2) | 406 (5.4) | 953 (34.3) | <0.001 |
| Renal support | 203 (2.0) | 140 (1.9) | 63 (2.3) | 0.206 |
| No of technology | <0.001 | |||
| 0 | 8160 (79.2) | 6528 (86.6) | 1632 (58.9) | |
| 1 | 1965 (19.1) | 952 (12.6) | 1013 (36.5) | |
| 2+ | 184 (1.8) | 57 (0.8) | 127 (4.6) |
CCC, complex, chronic conditions; GERD, gastro-oesophageal reflux disease; NI, neurological impairment.