KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, peptides, and recombinant proteins
Power SYBR Green Master Mix	Applied Biosystems	Cat# 43-679-59
Critical commercial assays
FGF21 ELISA	R&D Systems	Cat# MF2100
Adiponectin ELISA	ALPCO	Cat# 47-ADPMS-E01
Triglyceride Quantification Kit	Millipore Sigma	Cat# TRO100-1KT
Cholesterol Quantification Kit	BioVision	Cat# K603-100
Milliplex metabolic hormone multiple assay	Millipore	Cat# MMHMAG-44K
Deposited data
Hepatic RNA seq data	NIH SRA Database	PRJNA851959
Experimental models: Organisms/strains
Mouse strain: B6D2/F1	The Jackson Laboratory	Cat# 100006
Mouse strain: ATF4 flox	Chris Adams	Atf4tm1.1Cmad
Mouse strain: C57BL6/J	The Jackson Laboratory	Cat# 000664
Mouse strain: Albumin-Cre	The Jackson Laboratory	Cat# 003574
Oligonucleotides – see also Table S4
18s: F: CATGCAGAACCCACGACAGTA	This paper	N/A
18s: R: CCTCACGCAGCTTGTTGTCTA	This paper	N/A
Asns: F: GTCAAGAACTCCTGGTTCAAG	This paper	N/A
Asns: R: GATCTGACGGTAGAAGTAGC	This paper	N/A
Atf4: F: TCGATGCTCTGTTTCGAATG	This paper	N/A
Atf4: R: AGAATGTAAAGGGGGCAACC	This paper	N/A
Fgf21: F: CTGCTGGGGGTCTACCAAG	This paper	N/A
Fgf21: R: CTGCGCCTACCACTGTTCC	This paper	N/A
Psat1: F: CAGTGGAGCGCCAGAATAGAA	This paper	N/A
Psat1: R: CCTGTGCCCCTTCAAGGAG	This paper	N/A
Software and algorithms
R (4.0.2)	N/A	N/A
QIIME 2 (2020.2)	(Bolyen et al., 2019)	N/A
phyloseq (1.32.0)	(McMurdie and Holmes 2013)	N/A
qiime2R (0.99.34)	N/A	https://github.com/jbisanz/qiime2R
DEseq2 (1.28.1)	(Love et al., 2014)	N/A
Rsubread (2.3.7)	(Liao et al., 2019)	N/A
edgeR (3.30.3)	(Robinson et al., 2010)	N/A
clusterProfiler (3.16.0)	(Yu et al., 2012)	N/A
IsoCorrectoRGUI	(Heinrich et al., 2018)	N/A
Other
Normal maintenance mouse chow	Purina	Cat# 5053
Protein-free base diet	Research Diets	Cat# D12450BSpx