Table 3.

Functional annotation analysis of first 100 differentially expressed genes

Annotation cluster 1	Pathways enrichment score: 2.05	p-Value	Benjamini
INTERPRO	Neurotransmitter-gated ion-channel. conserved site	8.80 × 10−4	6.00 × 10−2
INTERPRO	Neurotransmitter-gated ion-channel transmembrane domain	1.00 × 10−3	6.00 × 10−2
INTERPRO	Neurotransmitter-gated ion-channel	1.00 × 10−3	6.00 × 10−2
INTERPRO	Neurotransmitter-gated ion-channel ligand binding	1.00 × 10−3	6.00 × 10−2
INTERPRO	Nicotinic acetylcholine receptor	2.40 × 10−3	1.20 × 10−1
UP_KEYWORDS	Synapse	2.80 × 10−3	2.20 × 10−1
UP_KEYWORDS	Ion channel	2.90 × 10−3	2.20 × 10−1
UP_KEYWORDS	Ligand-gated ion channel	3.90 × 10−3	2.20 × 10−1
GOTERM_MF_DIRECT	Acetylcholine receptor activity	4.20 × 10−3	3.50 × 10−1
GOTERM_MF_DIRECT	Acetylcholine-activated cation-selective channel activity	4.20 × 10−3	3.50 × 10−1
INTERPRO	Nicotinic acetylcholine-gated receptor, transmembrane domain	4.30 × 10−3	1.70 × 10−1
GOTERM_CC_DIRECT	Acetylcholine-gated channel complex	4.30 × 10−3	6.10 × 10−10
GOTERM_MF_DIRECT	Acetylcholine binding	5.30 × 10−3	3.50 × 10−1
UP KEYWORDS	Postsynaptic cell membrane	5.50 × 10−3	2.30 × 10−1
GOTERM_BP_DIRECT	Neuromuscular synaptic transmission	5.50 × 10−3	1.00 × 1000
GOTERM MF_DIRECT	Ligand-gated ion channel activity	1.00 × 10−2	4.90 × 10−1
GOTERM_BP_DIRECT	Synaptic transmission, cholinergic	1.10 × 10−2	1.00 × 1000

Annotation cluster 2	Pathways enrichment score: 1.93	p-value	Benjamini
KEGG_PATHWAY	RAS	4.60 × 10−6	3.60 × 10−4
GOTERM_BP_DIRECT	Proteolysis	2.00 × 10−2	1.00 × 1000
GOTERM_MF_DIRECT RT	Metallopeptidase activity	4.60 × 10−2	1.00 × 1000
UP_KEYWORDS	Protease	6.30 × 10−2	8.00 × 10−1

Annotation cluster 3	Pathways enrichment score: 0.83	p-value	Benjamini
UP_KEYWORDS	Zinc	4.50 × 10−1	1.00 × 1000
GOTERM_MF DIRECT	Zinc ion binding	2.20 × 10−1	1.00 × 1000
UP_KEYWORDS	Metal binding	3.60 × 10−1	1.00 × 1000
INTERPRO	Zinc finger C2H2-type/integrase DNA binding domain	7.90 × 10−1	1.00 × 1000
SMART	ZnF C2H2	7.90 × 10−1	1.00 × 1000
INTERPRO	Zinc finger, C2H2-like	8.20 × 10−1	1.00 × 1000
UP_KEYWORDS	Zinc finger	8.40 × 10−1	1.00 × 1000
UP_SEQ_FEATURE	Metal ion-binding site: zinc; catalytic	0.092	1
INTERPRO	Zinc finger, C2H2	8.40 × 10−1	1.00 × 1000