Table 3.

HRs (95% CIs) for mortality according to serum 25(OH)D concentrations among participants with OA

	Serum 25(OH)D concentrations (nmol/L)				P trend
	< 25.00	25.00–49.99	50.00–74.99	≥ 75.00
All-cause mortality
Number of deaths (%)	24 (24.00)	126 (21.39)	173 (18.12)	115 (12.61)
Model 1 HR (95% CI) P-value	1.00	0.78 (0.50, 1.20) 0.25	0.65 (0.42, 0.99) <0.05	0.59 (0.38, 0.92) 0.02	<0.01
Model 2 HR (95% CI) P-value	1.00	0.59 (0.38, 0.92) 0.02	0.42 (0.27, 0.66) <0.01	0.38 (0.24, 0.60) <0.01	<0.01
Model 3 HR (95% CI) P-value	1.00	0.53 (0.29, 0.96) 0.04	0.43 (0.24, 0.77) <0.01	0.44 (0.24, 0.81) <0.01	0.02
CVD mortality
Number of deaths (%)	4 (4.00)	20 (3.40)	31 (3.25)	19 (2.08)
Model 1 HR (95% CI) P-value	1.00	0.76 (0.26, 2.23) 0.62	0.73 (0.26, 2.06) 0.55	0.57 (0.19, 1.66) 0.30	0.09
Model 2 HR (95% CI) P-value	1.00	0.62 (0.21, 1.87) 0.40	0.47 (0.16, 1.40) 0.18	0.37 (0.12, 1.15) 0.08	0.57
Model 3 HR (95% CI) P-value	1.00	0.16 (0.04, 0.60) <0.01	0.19 (0.05, 0.68) 0.01	0.18 (0.05, 0.68) 0.01	0.41
Cancer mortality
Number of deaths (%)	3 (3.00)	20 (3.40)	34 (3.56)	21 (2.30)
Model 1 HR (95% CI) P-value	1.00	0.98 (0.29, 3.31) 0.98	1.00 (0.31, 3.26) 1.00	0.86 (0.26, 2.89) 0.81	0.24
Model 2 HR (95% CI) P-value	1.00	0.85 (0.25, 2.91) 0.80	0.81 (0.24, 2.73) 0.73	0.64 (0.18, 2.26) 0.49	0.10
Model 3 HR (95% CI) P-value	1.00	0.65 (0.17, 2.41) 0.52	0.63 (0.17, 2.35) 0.49	0.47 (0.12, 1.87) 0.28	0.40

Model 1: Non-adjusted

Model 2: Adjusted for age, sex, race/ethnicity, survey cycle

Model 3: Adjusted for age, sex, race/ethnicity, survey cycle, education level, PIR, BMI, smoking status, alcohol consumption, disease duration of OA, and history of hypertension or diabetes