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. 2022 Sep 21;23:199. doi: 10.1186/s13059-022-02770-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Epigenetic and chromatin interactions near the candidate GSH sites in blood and brain. a Genome browser screenshot of a representative GSH in blood. From top to bottom: Interaction heatmap and TADs from Hi-C in GM12878 cells. Chromatin interaction loops from promoter capture Hi-C in blood cells (see Method section for details). The coordinate of the GSH. Active and repressive genomic regions defined by 15-state ChromHMM from blood cells in the Roadmap project (Additional file 9: Table S8), and reference genes. b Genome browser screenshot of a representative GSH in brain. From top to bottom: Interaction heatmap and TADs from Hi-C in brain hippocampus. Chromatin interaction loops from promoter capture Hi-C in brain cells (dorsolateral prefrontal cortex, hippocampus, and neural progenitor cells). The coordinate of the GSH. Active and repressive genomic regions defined by 15-state ChromHMM from brain cells in the Roadmap project (Additional file 9: Table S8), and reference genes. Regions surrounding the GSH sites are highlighted with blue shade