Table 2. .
Examples of Vaccinia virus homologues (from BLASTS of the relevant HIV-1 env proteins versus Ankara, GLV-1h68, Tian Tian, and L-IPV Vaccinia strains) compared with the env glycoprotein from a selection of HIV-1 viral strains (various subtypes from groups M, N, and O).
| Group M subtype A (isolate Z321) (Accession # P05881) | Group M subtype B (isolate BRU/LAI) (Accession # P03377) | Group M subtype B (isolate BH10)(Accession # P03375) | Group M subtype C (isolate ETH2220) (Accession # Q75008) |
|---|---|---|---|
| 340: DTLSKV 388: TSGLF 524: GAAGST 488: VVKIEP 617: KSQSD 644: NLIEE 702:LL LSIIN 703: SIINR 841: LNIPR |
187: CSFNIS S 529: GAAGST 303: KLDII ID 493: VVKIEP 705: A LSIVN |
524: GAAGST |
154: CSFNI 391: LELFN 429: GIIMC 512: GAAGST 574: HLRDQ 629: IIYNL 690: LSIVN 685: IIFAV |
| Group M subtype D (isolate Z84) (Accession # P05882) |
Group M subtype F1 (isolate VI850) (Accession # Q9QSQ7) |
Group M subtype G (isolate 92NG083) (Accession # O41803) |
Group M subtype H (isolate 90CF056) (Accession #O70902) |
| 63:EAHNI 197: NTNYT Y 291: NNVKTII 364: LNQTT 495: VV IEP 531: GAAGST |
377: TSGLF 386: SNNGT 678: LSIVN 696: LIPSP 753: IAARI 768: ALKYL 771: YLGNL 817: LNIPR |
329: NVSRI 352: NKNIT 383: TSGLF 392: SNINN 473: KTVK+K 510: GAAGST 688: LSIVN |
661: WFDIS 690: LSIVN 752: LSLFS |
| Group M subtype J (isolate SE9173) (Accession # Q9WC69) |
Group M subtype K (isolate 96CM-MP535) (Accession # Q9QBY2) |
Group N (isolate YBF106) (Accession # Q9IDV2) |
Group O (isolate ANT70)(Accession #Q77377) |
| 146: SPEIM N 180: INSDN 194: TSVIK 482: VVELEP 615: DIWEN 691: IIFAV |
187: NNSST 448: NTHNE 510: GAAGST 732: VRLVS 797: AISLL |
74: LLTNV 79: TEYFN 134: +RTEDL 156: RDRKK 250: QLILN 476: VSREK 513: RTLLS 787: LKDSAI |
254: QLILN 544: HTLLK 696: RVIMI 698: IMIVL 704: IVKNIR+G |
Identical peptides (HIV-1 = Vaccinia) were analyzed for B cell antigenicity using the BepiPred server and those predicted as epitopes are highlighted in bold.