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. 2022 Apr 18;35(3):e00150-21. doi: 10.1128/cmr.00150-21

TABLE 4.

Class C β-lactamases and species-specific progenitors

Enzyme/straina First identification Updated identification %b References
ACC-1*c Hafnia alvei Hafnia paralvei 99.7 321, this review
ACT-1*c Enterobacter cloacae Enterobacter asburiae 98.4 322, this review
Aer-1 Enterobacter aerogenes Klebsiella aerogenes 98.9 338, 363
AQU-1 Aeromonas aquariorum Aeromonas dhakensis 99.2 249, 364
AsbA1 Aeromonas sobria Aeromonas jandaei 94.5 324, this review
BIL-1* Citrobacter freundii Citrobacter portucalensis 96.8 326, this review
BUT-1 Buttiauxella sp. Scandinavium goeteborgense 99.0 329, 365
BUT-2 Buttiauxella agrestis Scandinavium goeteborgense 99.5 339, 365
CAV-1 Aeromonas caviae Aeromonas allosaccharophila 97.1 44, 71
CFE-1* Citrobacter freundii Citrobacter europaeus 99.2 208, this review
CFE-2* Citrobacter freundii Citrobacter werkmanii 95.0 366, this review
CMY-1*c Aeromonas hydrophila Aeromonas sanarellii 95.3 233, this review
CMY-2* Citrobacter freundii Citrobacter portucalensis 98.4 335, this review
EDC-1 Edwardsiella tarda Edwardsiella piscicida 99.1 This review
FOX-1* Aeromonas caviae Aeromonas allosaccharophila 94-98 71, 341
LAT-1* Citrobacter freundii Citrobacter portucalensis 97.4 345, this review
MIR-1*c Enterobacter cloacae Enterobacter roggenkampii 99.7 25, 352
MOX-1* Aeromonas hydrophila Aeromonas sanarellii 94.5 72, 232
MOX-2* Aeromonas sp. Aeromonas caviae 98.9 72, 234
MOX-9* Aeromonas caviae Aeromonas media 98.0 72, 367
P99 (ACT-89) Enterobacter cloacae Enterobacter hormaechei 97.9 25, 352, this review
TRU-1 Aeromonas tructi Aeromonas enteropelogenes 97.1 360, this review
a

Plasmid-encoded enzymes are labeled by an asterisk.

b

Percentage of identity with consensus sequence.

c

Other plasmid-encoded types: ACC-4 (99.5% for H. paralvei); ACT-3, ACT-6, ACT-8, and ACT-10 (97.6% for E. asburiae); CMY-17, CMY-55, CMY-132, and CMY-161 (≥ 98.1% for A. sanarellii); MIR-4 (99.4% for E. roggenkampii). Their respective phylogenies can be found in references 32, 46, 50, and 63; and 73 and 74.