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. 2022 Jul 6;35(3):e00008-21. doi: 10.1128/cmr.00008-21

TABLE 11.

Shigella human challenge models

Species Serotype Strain(s) Typical dose range evaluated (CFU) No. of challenges administered
Shigella flexneri 2a 2457T 102 to 104 456
FW I to FW V 108 to 1010
Shigella sonnei NAa 53G 5 × 102 178
Shigella dysenteriae 1 A-1, M-131 102 to 104 44
a

NA, not applicable, since S. sonnei has a single serotype.