TABLE 16.

Currently licensed Salmonella Typhi vaccines

Licensed vaccine and trade name	Description	Developer(s)
Not applicable	Killed whole-cell vaccine	Not currently manufactured due to high rates of reactogenicity
Ty21a (Vivotif)	Live-attenuated, oral licensed for adults and children older than 5 years of age	Emergent
Vi CPS (various)	Parenteral Vi (capsular polysaccharide antigen) vaccine licensed for adults and children 2 years of age and older	GlaxoSmithKline, Sanofi Pasteur, Bharat Biotech, BioMed, Finlay Institute, and approximately six other manufacturers located in countries of endemicity
Vi conjugate (Typbar-TCV, Peda-Typh, Typhibev)	Parenteral Vi conjugated to tetanus toxoid (Typbar-TCV, Peda-Typh) or diphtheria toxoid CRM197 (Typhibev) carrier protein, licensed in India for adults and children 6 months of age and older	Bharat Biotech (Typbar-TCV), Bio-Med (Peda-Typh), Biological E (Typhibev)