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Human carriage model for pneumococcus
| Method of production and administration | Challenge strain | Strain provider |
|---|---|---|
| Laboratory cultivation is used to freshly prepare and titrate the challenge inoculum. The inoculum is administered to healthy adult volunteers by intranasal instillation in doses ranging from 10,000 to 140,000 CFU. | P833, a type 23F clinical isolate | Jeffrey Weiser, University of Pennsylvania |
| BHN418, a type 6B clinical isolate | Peter Hermans, University of Nijmegen |
