TABLE 6.

Human challenge studies with Vibrio cholerae after administration of candidate vaccines

Vaccine	No. of volunteers	Challenge strain	Reference
Dukoral with or without cholera toxin B subunit	35	O1 El Tor Inaba	Black, 1987 (228)
Live-attenuated vaccine CVD 112, based on a serogroup O139 strain of V. cholerae	23	O139	Tacket, 1995 (229)
Live-attenuated vaccine CVD 111, based on an O1 El Tor Ogawa strain of V. cholerae	26	O1 El Tor Ogawa	Tacket, 1997 (230)
Live-attenuated vaccine CVD 103-HgR, based on an O1 classical Inaba strain of V. cholerae	51	O1 El Tor Inaba	Tacket, 1999 (210)
Peru-15, a live-attenuated vaccine based on an O1 El Tor Inaba strain of V. cholerae	36	O1 El Tor Inaba	Cohen, 2002 (231)
V. cholerae 638, a live-attenuated vaccine based on an O1 El Tor Ogawa strain	21	O1 El Tor Ogawa	Garcia, 2005 (232)
Live-attenuated vaccine CVD 103-HgR (Vaxchora formulation)	197	O1 El Tor Inaba	Chen, 2016 (211)