Table 3.
Selected molecules of interest trapped inside the digested microclots of high-responder long COVID patients (N = 66) vs all controls (N = 29)
| Immunoglobulin molecules (or fragments thereof) that were found to be INCREASED in the long COVID (high responder) sample vs the healthy sample | |||
|---|---|---|---|
| Uniprot ID | Molecule | Fold change | p-Value |
| P01876 |
Immunoglobulin alpha-1 chain C region (IGHA1_HUMAN) |
1.5 | 1.2 × 10− 05 |
| A0A0C4DH32 |
Immunoglobulin heavy chain V-III region GAL (HV320_HUMAN) |
1.6 | 5 × 10− 05 |
| P01602 | Immunoglobulin kappa chain V-I region HK102 (Fragment) (KV105_HUMAN) | 1.6 | 0.0003 |
| B9A064 |
Immunoglobulin lambda-like polypeptide 5 (IGLL5_HUMAN) |
1.7 | 2.5 × 10− 11 |
| P01717 |
Immunoglobulin lambda chain V-IV region Hil (LV403_HUMAN) |
1.8 | 1.7 × 10− 05 |
| P01763 |
Immunoglobulin heavy chain V-III region WEA (HV348_HUMAN) |
1.9 | 0.005 |
| P01764 |
Immunoglobulin heavy chain V-III region TUR (HV323_HUMAN) |
2.1 | 2.4 × 10− 05 |
| P04433 | Immunoglobulin kappa chain V-III region VG (Fragment) (KV311_HUMAN) | 2.4 | 1.5 × 10− 13 |
| P04207 |
Immunoglobulin kappa chain V-III region CLL (B chronic lymphocytic leukaemia) [32] (KV315_HUMAN) CD5- B cell CLL cell population might produce pathologic IgM kappa rheumatoid factor autoantibodies [33] |
2.3 | 2.9 × 10− 08 |
| P01624 |
Immunoglobulin kappa chain V-III region POM (plasma membrane) (KV315_HUMAN) rheumatoid factor |
2.3 | 0.01 |
| P04211 |
Immunoglobulin lambda chain V region 4A (LV743_HUMAN) |
2.5 | 0.003 |
| P06331 | Immunoglobulin heavy chain V-II region ARH-77 (HV434_HUMAN) | 2.7 | 0.002 |
| P04430 |
Immunoglobulin kappa chain V-I region BAN (KV116_HUMAN) |
2.8 | 2.7 × 10− 06 |
| P01762 |
Immunoglobulin heavy chain V-III region TRO (HV311_HUMAN) |
2.8 | 1.0 × 10− 08 |
| P01619 | Immunoglobulin kappa chain V-III region NG9 (Fragment) (KV320_HUMAN) | 2.9 | 7.3 × 10− 05 |
| P01619 |
Immunoglobulin kappa chain V-III region B6 (KV320_HUMAN) |
3.8 | 4.1 × 10− 06 |
| P80748 |
Immunoglobulin lambda chain V-V region DEL (LV321_HUMAN) |
3.8 | 1.2 × 10− 08 |
| P01780 |
Immunoglobulin heavy chain V-III region JON (HV307_HUMAN) |
4.0 | 0.002 |
| P01772 |
Immunoglobulin heavy chain V-III region KOL (HV333_HUMAN) |
4.2 | 1.1 × 10− 05 |
| P01700 |
Immunoglobulin lambda chain V-I region HA (LV147_HUMAN) |
4.6 | 2.3 × 10− 06 |
| P01767 |
Immunoglobulin heavy chain V-III region BUT (HV353_HUMAN) |
5.0 | 1.8 × 10− 06 |
| P06312 |
Immunoglobulin kappa chain V-IV region Len (KV401_HUMAN) |
5.6 | 9.9 × 10− 21 |
| P01700 |
Immunoglobulin lambda chain V-I region WAH (LV147_HUMAN) |
14.8 | 2.4 × 10− 08 |
| P01593 |
Immunoglobulin kappa chain V-I region Ni (KVD33_HUMAN) |
76.0 | 4.5 × 10− 42 |
Fold changes and P values of immunoglobulin molecules (or fragments thereof) that were found to be increased in the long COVID high responder population compared to our healthy controls are shown here (p = 0.01). Immunoglobulin molecules are either present or absent and therefore we only listed molecules (or fragments thereof) that were noted to be increased. We excluded immunoglobulin molecules (or fragments thereof) that were reduced compared to our healthy controls. Descriptions of the molecules are taken from the Uniprot website and were added in the description column. After cross referencing each immunoglobulin on THE INTERNATIONAL IMMUNOGENETICS INFORMATION SYSTEM®’s IMGT/LIGM-DB database a datafile containing a description of the immunoglobulin, the nucleotide sequence, other data and literature references can be downloaded. The descriptions listed below were obtained from these data files