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. 2022 Sep 21;23:263. doi: 10.1186/s12931-022-02173-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — A Distribution of all VO₂max values (measured in % predicted) derived from CPET. B VO₂max values over time, ± SD. C mean select individual CPET values, ± SD. D Association between A-aDO₂ on exertion and VO₂max (top panel) as well as the association between D_LCO and VO₂max. E VO₂max values based on initial treatment setting over time ± SD. Significance assessed by ANOVA and post-hoc Tukey test. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001