TABLE 1.
Demographic and clinical characteristics of OCD patients, their unaffected siblings and healthy controls
| OCD patients (n = 28) | Siblings (n = 8) | HC (n = 28) | Analysis | |
|---|---|---|---|---|
| Mean (±SD) | Mean (±SD) | Mean (±SD) | F (p value) | |
| Demographic variables | ||||
| Age1 | 36.8 (±9.2) | 37.8 (±13.2) | 40.6 (±11.0) | 0.99 (.378) |
| Education1 | 13.6 (±3.4) | 12.3 (±2.4) | 12.2 (±2.8) | 1.55 (.219) |
| Sex (M/F) | 11/17 | 4/4 | 12/18 | 0.14 (.866) |
| Clinical variables | ||||
| Disease duration1 | 22.7 (±11.3) | 0 | 0 | 66.5 (<.001) |
| Y‐BOCS (total score) | 21.3 (±6.0) | 0.1 (±0.4) | 0 | 220 (<.001) |
| Y‐BOCS obsessions | 10.3 (±3.6) | 0.1 (±0.4) | 0 | 146 (<.001) |
| Y‐BOCS compulsions | 11.0 (±3.0) | 0 | 0 | 236 (<.001) |
| OCI‐R (total score) | 22.8 (±11.7) | 2.9 (±2.9) | 3.3 (±5.4) | 37.3 (<.001) |
| OCI‐R washing | 3.0 (±3.6) | 0 | 0.4 (±0.7) | 7.97 (<.001) |
| OCI‐R checking | 6.4 (±4.2) | 0.6 (±0.9) | 0.3 (±0.6) | 32.5 (<.001) |
| OCI‐R ordering | 4.4 (±3.7) | 0.4 (±0.7) | 0.9 (±1.8) | 12.4 (<.001) |
| OCI‐R obsession | 4.9 (±3.5) | 0.6 (±1.2) | 0.4 (±1.6) | 21.1 (<.001) |
| OCI‐R hoarding | 1.8 (±2.6) | 1.1 (±1.4) | 1.2 (±2.2) | 0.4 (0.67) |
| OCI‐R neutralizing | 2.1 (±3.0) | 0.1 (±0.4) | 0.1 (±0.2) | 7.46 (<.001) |
| MADRS | 9.3 (±6.9) | 1.3 (±2.9) | 1.0 (±1.6) | 20.6 (<.001) |
Note: 1 expressed in years.
Abbreviations: HC, healthy controls; MADRS, Montgomery‐Åsberg Depression Rating Scale; OCI‐R, obsessive–compulsive inventory revised; SD, standard deviation of the mean; Y‐BOCS, yale‐brown obsessive–compulsive scale.