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. 2022 Sep 7;13:952140. doi: 10.3389/fphys.2022.952140

TABLE 5.

Summary of all HR-pQCT parameters at the distal tibia.

Control Vibration
Contrast % change p-value 95% lower bound 95% upper bound Contrast % change p-value 95% lower bound 95% upper bound p-value group*month p-value month
Total BMD (mgHA/cm3) p = 0.0063 p = 0.149
Month 6 vs. Baseline 0.108 0.04 1.000 −1.107 1.323 −1.009 −0.40 0.154 −2.201 0.184
Month 12 vs. Baseline −1.841 −0.71 0.023 −3.517 −0.164 −1.346 −0.53 0.014 −2.509 −0.183
Month 18 vs. Baseline −2.186 −0.85 0.007 −3.970 −0.402 −3.187 −1.26 0.000 −4.565 −1.809
Trabecular vBMD (mgHA/cm3) p = 0.0159 p = 0.076
Month 6 vs. Baseline 0.257 0.17 1.000 −0.508 1.021 0.082 0.05 1.000 −0.675 0.839
Month 12 vs. Baseline −0.828 −0.54 0.165 −1.819 0.163 0.290 0.19 1.000 −0.456 1.036
Month 18 vs. Baseline −0.769 −0.50 0.576 −1.989 0.450 −0.198 −0.13 1.000 −1.116 0.721
BV/TV (%) p = 0.0231 p = 0.049
Month 6 vs. Baseline 0.000 0.17 1.000 0.000 0.001 0.000 0.10 1.000 −0.001 0.001
Month 12 vs. Baseline −0.001 −0.52 0.213 −0.002 0.000 0.000 0.23 1.000 0.000 0.001
Month 18 vs. Baseline −0.001 −0.52 0.506 −0.002 0.000 0.000 −0.11 1.000 −0.001 0.001
Trabecular inhomogeneity (Tb.1/N.SD; mm) p = 0.3615 p = 0.149
Month 6 vs. Baseline 0.002 0.57 1.000 −0.006 0.009 0.005 1.47 1.000 −0.009 0.019
Month 12 vs. Baseline 0.003 1.17 1.000 −0.011 0.018 0.017 4.91 0.159 −0.003 0.038
Month 18 vs. Baseline 0.005 1.69 1.000 −0.007 0.017 0.010 2.90 0.962 −0.009 0.029
Cortical area (mm2) p = 0.1317 p = 0.822
Month 6 vs. Baseline 0.359 0.37 1.000 −1.247 1.966 0.127 0.14 1.000 −0.857 1.110
Month 12 vs. Baseline −0.306 −0.32 1.000 −1.837 1.226 0.267 0.29 1.000 −0.798 1.332
Month 18 vs. Baseline 0.470 0.49 1.000 −0.932 1.873 −0.208 −0.22 1.000 −1.326 0.911
Cortical vBMD (mgHA/cm3) p = 0.9484 p = 0.049
Month 6 vs. Baseline −3.907 −0.49 0.034 −7.637 −0.176 −6.048 −0.75 0.000 −9.305 −2.790
Month 12 vs. Baseline −6.078 0.76 0.002 −10.503 −1.654 −9.481 −1.18 0.000 −13.111 −5.851
Month 18 vs. Baseline −9.814 −1.23 0.000 −14.344 −5.284 −13.523 −1.68 0.000 −17.747 −9.299
Cortical perimeter (mm) p = 0.3602 p = 0.065
Month 6 vs. Baseline −0.155 −0.16 0.216 −0.349 0.040 −0.147 −0.15 0.280 −0.341 0.048
Month 12 vs. Baseline 0.790 0.79 1.000 −1.792 3.371 −0.413 −0.41 0.001 −0.691 −0.136
Month 18 vs. Baseline −0.258 −0.26 0.082 −0.534 0.018 −0.408 −0.41 0.002 −0.709 −0.107
Cortical thickness (mm) p = 0.3772 p = 0.972
Month 6 vs. Baseline −0.001 −0.05 1.000 −0.014 0.013 −0.001 −0.09 1.000 −0.012 0.011
Month 12 vs. Baseline −0.001 −0.13 1.000 −0.015 0.012 0.002 0.22 1.000 −0.009 0.014
Month 18 vs. Baseline 0.000 0.01 1.000 −0.012 0.012 0.000 −0.03 1.000 −0.013 0.013
Cortical porosity (%) p = 0.6070 p = 0.559
Month 6 vs. Baseline 0.001 1.52 1.000 −0.002 0.005 0.002 2.81 0.094 0.000 0.004
Month 12 vs. Baseline 0.003 3.79 0.147 −0.001 0.007 0.005 6.50 0.000 0.002 0.007
Month 18 vs. Baseline 0.005 6.23 0.003 0.001 0.009 0.006 7.82 0.000 0.003 0.008
Ultimate load (N) p = 0.8138 p = 0.145
Month 6 vs. Baseline 30.062 −0.37 1.000 −65.523 125.647 70.369 −0.88 0.299 −24.280 165.017
Month 12 vs. Baseline 74.798 −0.93 0.484 −38.158 187.754 86.170 −1.07 0.312 −30.849 203.190
Month 18 vs. Baseline 61.717 −0.77 0.883 −50.621 174.056 131.971 −1.65 0.019 14.108 249.835
Trabecular load vs. whole bone load (distal) p = 0.4204 p = 0.016
Month 6 vs. Baseline −0.006 −1.13 0.278 −0.014 0.002 −0.005 −0.90 0.566 −0.012 0.003
Month 12 vs. Baseline −0.002 −0.46 1.000 −0.011 0.006 −0.011 −2.07 1.000 −0.033 0.011
Month 18 vs. Baseline −0.006 −1.18 0.363 −0.015 0.002 −0.001 −0.27 1.000 −0.010 0.007
Trabecular load vs. whole bone load (proximal) p = 0.4699 p = 0.185
Month 6 vs. Baseline −0.004 −1.30 0.872 −0.012 0.003 −0.002 −0.66 1.000 −0.009 0.005
Month 12 vs. Baseline 0.000 −0.03 1.000 −0.008 0.008 −0.009 −2.63 0.925 −0.025 0.007
Month 18 vs. Baseline −0.003 −0.85 1.000 −0.012 0.007 −0.001 −0.34 1.000 −0.009 0.007
Trabecular Von Mises stress (MPa) p = 0.8662 p = 0.156
Month 6 vs. Baseline −0.473 −0.90 1.000 −1.566 0.619 −0.573 −1.06 1.000 −1.762 0.616
Month 12 vs. Baseline −0.379 −0.72 1.000 −1.595 0.837 −1.270 −2.35 0.516 −3.222 0.682
Month 18 vc Baseline −0.487 −0.92 1.000 −1.793 0.819 −1.022 −1.89 0.349 −2.445 0.401
Cortical Von Mises stress (MPa) p = 0.0927 p = 0.477
Month 6 vs. Baseline −0.135 −0.16 1.000 −0.431 0.162 −0.179 −0.21 0.334 −0.425 0.068
Month 12 vs. Baseline −0.232 −0.27 0.194 −0.518 0.054 0.011 0.01 1.000 −0.295 0.318
Month 18 vs. Baseline −0.146 −0.17 1.000 4.446 0.155 −0.226 −0.26 0.588 −0.586 0.134
Total Muscle Volume (mm3) p = 0.5400 p = 0.008
Month 6 vs. Baseline 37.341 0.19 1.000 454252 528.935 −115.230 −0.61 1.000 450.794 220.333
Month 12 vs. Baseline 166.399 0.85 1.000 −356.981 689.779 −166.633 −0.89 1.000 −536.316 203.050
Month 18 vs. Baseline −117.924 −0.60 1.000 −471.104 235.255 −256.935 −1.37 0.224 −582.550 68.679
MV/TV p = 0.1708 p = 0.914
Month 6 vs. Baseline −0.002 −0.41 1.000 −0.011 0.007 0.000 −0.04 1.000 −0.007 0.006
Month 12 vs. Baseline −0.009 −1.62 0.062 −0.018 0.000 0.001 0.13 1.000 −0.007 0.008
Month 18 vs. Baseline −0.006 −1.11 0.776 −0.017 0.005 −0.003 −0.51 1.000 −0.011 0.005