TABLE 6.
Summary of all HR-pQCT parameters at the distal radius.
| Control | Vibration | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Contrast | % change | p-value | 95% lower bound | 95% upper bound | Contrast | % change | p-value | 95% lower bound | 95% upper bound | p-value group*month | p-value month | |
| Total BMD (mgHA/cm3) | p = 0.4353 | p = 0.092 | ||||||||||
| Month 6 vs. Baseline | 0.51 | 0.17 | 1.00 | −1.87 | 2.89 | −0.95 | −0.32 | 1.00 | −3.25 | 1.36 | ||
| Month 12 vs. Baseline | −1.93 | −0.65 | 0.25 | −4.43 | 0.58 | −1.73 | −0.59 | 0.58 | −4.47 | 1.01 | ||
| Month 18 vs. Baseline | −3.71 | −1.25 | 0.08 | −7.66 | 0.25 | −4.09 | −1.39 | 0.00 | −6.92 | −1.26 | ||
| Trabecular vBMD (mgHA/cm3) | p = 0.5609 | p = 0.010 | ||||||||||
| Month 6 vs. Baseline | 0.04 | 0.03 | 1.00 | −0.98 | 1.06 | 0.10 | 0.07 | 1.00 | −0.95 | 1.15 | ||
| Month 12 vs. Baseline | −0.75 | −0.50 | 0.48 | −1.89 | 0.38 | 0.25 | 0.17 | 1.00 | −1.00 | 1.50 | ||
| Month 18 vs. Baseline | −2.28 | −1.52 | 0.12 | −4.85 | 0.29 | −0.78 | −0.54 | 0.83 | −2.16 | 0.61 | ||
| BV/TV (%) | p = 0.0112 | p = 0.011 | ||||||||||
| Month 6 vs. Baseline | 0.00 | 0.05 | 1.00 | 0.00 | 0.00 | 0.00 | 0.09 | 1.00 | 0.00 | 0.00 | ||
| Month 12 vs. Baseline | 0.00 | −0.54 | 0.39 | 0.00 | 0.00 | 0.00 | 0.22 | 1.00 | 0.00 | 0.00 | ||
| Month 18 vs. Baseline | 0.00 | −1.52 | 0.11 | 0.00 | 0.00 | 0.00 | −0.53 | 0.88 | 0.00 | 0.00 | ||
| Trabecular inhomogeneity (Tb.1/N.SD; mm) | p = 0.1465 | p = 0.037 | ||||||||||
| Month 6 vs. Baseline | 0.01 | 2.45 | 0.27 | 0.00 | 0.02 | 0.01 | 4.13 | 0.02 | 0.00 | 0.03 | ||
| Month 12 vs. Baseline | 0.00 | 1.49 | 1.00 | −0.01 | 0.02 | 0.01 | 3.30 | 1.00 | −0.01 | 0.03 | ||
| Month 18 vs. Baseline | 0.01 | 2.52 | 0.27 | 0.00 | 0.02 | 0.01 | 4.13 | 0.26 | 0.00 | 0.03 | ||
| Cortical area (mm2) | p = 0.3697 | p = 0.260 | ||||||||||
| Month 6 vs. Baseline | 0.37 | 0.75 | 0.88 | −0.30 | 1.04 | −0.19 | −0.39 | 1.00 | −0.73 | 0.36 | ||
| Month 12 vs. Baseline | −0.02 | −0.03 | 1.00 | −0.80 | 0.77 | −0.14 | −0.28 | 1.00 | −0.69 | 0.42 | ||
| Month 18 vs. Baseline | 1.51 | 3.10 | 1.00 | −2.81 | 5.84 | −0.55 | −1.14 | 0.18 | −1.23 | 0.12 | ||
| Cortical vBMD (mgHA/cm3) | p = 0.4968 | p = 0.582 | ||||||||||
| Month 6 vs. Baseline | −0.92 | −0.11 | 1.00 | −5.36 | 3.51 | −3.55 | −0.41 | 0.22 | −8.05 | 0.94 | ||
| Month 12 vs. Baseline | −3.86 | −0.46 | 0.40 | −9.43 | 1.70 | −6.90 | −0.80 | 0.00 | −11.65 | −2.15 | ||
| Month 18 vs. Baseline | −11.69 | −1.38 | 0.52 | −29.67 | 6.28 | −7.65 | −0.89 | 0.00 | −12.45 | −2.85 | ||
| Cortical perimeter (mm) | p = 0.1963 | p = 0.056 | ||||||||||
| Month 6 vs. Baseline | −1.37 | −1.99 | 1.00 | −4.18 | 1.45 | −0.08 | −0.11 | 1.00 | −0.31 | 0.16 | ||
| Month 12 vs. Baseline | −1.49 | −2.17 | 0.97 | −4.30 | 1.32 | −0.23 | −0.35 | 0.04 | −0.45 | −0.01 | ||
| Month 18 vs. Baseline | −1.54 | −2.24 | 0.89 | −4.35 | 1.27 | −0.36 | −0.55 | 0.00 | −0.61 | −0.12 | ||
| Cortical thickness (mm) | p = 0.1879 | p = 0.616 | ||||||||||
| Month 6 vs. Baseline | 0.00 | 0.55 | 1.00 | −0.01 | 0.02 | −0.01 | −0.71 | 0.30 | −0.01 | 0.00 | ||
| Month 12 vs. Baseline | 0.00 | −0.10 | 1.00 | −0.01 | 0.01 | 0.00 | −0.30 | 1.00 | −0.01 | 0.01 | ||
| Month 18 vs. Baseline | 0.01 | 1.49 | 1.00 | −0.03 | 0.06 | −0.01 | −0.71 | 0.86 | −0.02 | 0.00 | ||
| Cortical porosity (%) | p = 0.7435 | p = 0.059 | ||||||||||
| Month 6 vs. Baseline | 0.00 | 7.22 | 0.35 | 0.00 | 0.00 | 0.00 | 8.05 | 0.05 | 0.00 | 0.00 | ||
| Month 12 vs. Baseline | 0.00 | 8.08 | 0.21 | 0.00 | 0.00 | 0.00 | 8.74 | 0.06 | 0.00 | 0.00 | ||
| Month 18 vs. Baseline | 0.01 | 56.38 | 0.98 | −0.01 | 0.04 | 0.00 | 14.13 | 0.00 | 0.00 | 0.00 | ||
| Ultimate load (N) | p = 0.3537 | p = 0.005 | ||||||||||
| Month 6 vs. Baseline | 18.16 | −0.64 | 1.00 | −55.29 | 91.61 | 52.41 | −1.81 | 0.94 | −45.08 | 149.90 | ||
| Month 12 vs. Baseline | 80.07 | −2.80 | 0.00 | 16.85 | 143.28 | 64.08 | −2.21 | 0.01 | 11.54 | 116.62 | ||
| Month 18 vs. Baseline | 39.49 | −1.38 | 0.93 | −33.88 | 112.87 | 86.96 | −3.00 | 0.00 | 25.80 | 148.13 | ||
| Trabecular load vs. whole bone load (distal) | p = 0.4963 | p<0.001 | ||||||||||
| Month 6 vs. Baseline | 0.00 | −0.39 | 1.00 | −0.02 | 0.01 | 0.00 | 0.81 | 1.00 | −0.01 | 0.02 | ||
| Month 12 vs. Baseline | −0.01 | −2.84 | 0.16 | −0.03 | 0.00 | −0.01 | −2.49 | 0.39 | −0.03 | 0.00 | ||
| Month 18 vs. Baseline | 0.01 | 1.41 | 1.00 | −0.01 | 0.02 | 0.00 | −0.10 | 1.00 | −0.02 | 0.02 | ||
| Trabecular load vs. whole bone load (proximal) | p = 0.3569 | p = 0.008 | ||||||||||
| Month 6 vs. Baseline | 0.00 | −3.03 | 0.66 | −0.01 | 0.00 | 0.00 | 0.69 | 1.00 | −0.01 | 0.01 | ||
| Month 12 vs. Baseline | −0.01 | −3.52 | 0.49 | −0.01 | 0.00 | 0.00 | −2.17 | 1.00 | −0.01 | 0.00 | ||
| Month 18 vs. Baseline | 0.00 | 0.40 | 1.00 | −0.01 | 0.01 | 0.00 | 0.43 | 1.00 | −0.01 | 0.01 | ||
| Trabecular Von Mises stress (MPa) | p = 0.8640 | p = 0.009 | ||||||||||
| Month 6 vs. Baseline | −0.14 | −0.34 | 1.00 | −1.66 | 1.37 | −0.27 | −0.62 | 1.00 | −1.99 | 1.45 | ||
| Month 12 vs. Baseline | −1.44 | −3.38 | 0.11 | −3.05 | 0.17 | −1.08 | −2.48 | 0.33 | −2.56 | 0.40 | ||
| Month 18 vs. Baseline | 0.02 | 0.06 | 1.00 | −1.64 | 1.68 | −0.62 | −1.43 | 1.00 | −2.24 | 0.99 | ||
| Cortical Von Mises stress (MPa) | p = 0.4670 | p = 0.175 | ||||||||||
| Month 6 vs. Baseline | −0.34 | −0.43 | 1.00 | −1.25 | 0.57 | −1.15 | −1.44 | 1.00 | −3.38 | 1.08 | ||
| Month 12 vs. Baseline | −0.70 | −0.89 | 0.27 | −1.63 | 0.22 | −0.41 | −0.51 | 0.94 | −1.16 | 0.35 | ||
| Month 18 vs. Baseline | −0.92 | −1.16 | 0.40 | −2.23 | 0.40 | −0.71 | −0.88 | 0.06 | −1.43 | 0.02 | ||