Table 3. Diagnostic criteria of anti-NMDAR encephalitis (Adapted from Dalmau et al., 2019).

Probable
Rapid onset (<3 months) of at least four of the six major groups of symptoms: Group 1: Psychiatric symptoms: abnormal(psychiatric) behavior or cognitive dysfunction Group 2: Language: Speech dysfunction ( pressured speech, verbal reduction, or mutism) Group 3: Seizures Group 4: Movement disorders: dyskinesias, rigidity, or abnormal postures Group 5: Decreased level of consciousness Group 6: Autonomic dysfunction or central hypoventilation
And at least one of the laboratory studies: Abnormal EEG (focal or diffuse slow or disorganized activity, epileptic activity, or extreme delta brush) CSF with pleocytosis or oligoclonal bands
Or 3 of the above groups of symptoms and identification of a systemic teratoma
Exclusion of recent history of herpes simplex virus encephalitis or Japanese B encephalitis, which might result in relpasong immune-mediated neurological symptoms
Definite
One or more of the six major groups of symptoms and IgG GluN1 antibodies (antibody testing should include CSF); if only serum is available, confirmatory tests should be included (eg, live neurons or tissue immunohistochemistry, in addition to a cell-based assay)
Exclusion of recent history of herpes simplex virus encephalitis or Japanese B encephalitis, which might result in relapsing immune-mediated neurological symptoms