Table 3.
Stability Data for Free and Total Phenolic Benzotriazoles in Male SD Rat Plasma
| Analyte | Stability (RE, %)a | Number of Days Stored |
|---|---|---|
| Free Analysis | ||
| P-BZT | ≤ ± 6.8 | 231 |
| Octrizole | ≤ ± 13.6 | 251 |
| Drometrizole | ≤ ± 31.6 | 300 |
| tBuPrOcEst-BZT | ≤ ± 22.0 | 330 |
| Bumetrizole | ≤ ± 66.5 | 387 |
| DiMeEtPh-BZT | ≤ ± 33.6 | 332 |
| ditBuCl-BZT | ≤ ± 29.8 | 362 |
| DitPe-BZT | ≤ ± 20.9 | 365 |
| tBu-BZT | ≤ ± 61.0 | 350 |
| Total Analysis | ||
| P-BZT | ≤ ±12.3 | 306 |
| Octrizole | ≤ ± 27.1 | 328 |
| Drometrizole | ≤ ± 32.9 | 316 |
| tBuPrOcEst-BZT b | ≤ ± 73.7 | 705 |
| Bumetrizole | ≤ ± 9.4 | 399 |
| DiMeEtPh-BZT | ≤ ± 44.2 | 359 |
| ditBuCl-BZT | ≤ ± 40.2 | 364 |
| DitPe-BZT | ≤ ± 18.4 | 370 |
| tBu-BZT | ≤ ± 58.7 | 372 |
a
RE %= percent loss relative to Day 0, three replicates plasma QCs at 10 ng/mL stored at ∼ −70°C
b
With respect to tBuPrOcEst-BZT