Table 3. Selection of manually curated genes of interest according to number of significant signals close or within their CDS.
| 2308W | 2308 | Name | Function |
|---|---|---|---|
| Genes with 5 binding sites | |||
| BAW_11618 | BAB1_1695 | purA | Adenylosuccinate synthetase, important for virulence [17] |
| BAW_20068 | BAB2_0068 | virB1 | Type IV secretion system protein VirB1, important for virulence, important for virulence [60] |
| BAW_11934 | BAB1_2018 | zntR | Zn responsive regulator of zntA, important for virulence [61] |
| BAW_11935 | BAB1_2019 | zntA | Zn exporter, important for virulence [61] |
| BAW_11873 | BAB1_1956 | BAW_11873 | ABC transporter permease binding-protein dependent transport system inner membrane protein |
| BAW_11874 | BAB1_1957 | BAW_11874 | Arginine ABC transporter ATP-binding protein |
| Genes with 4 binding sites | |||
| BAW_12005 | BAB1_2090 -BAB1_2091 | pckA | Pseudogene. Premature stop codon. Similar to BS1330_I2083 and BruAb1_2064; phosphoenolpyruvate carboxykinase (ATP). A pckA mutation in B. abortus 2308 has no effect in Raw 264.7 macrophage intracellular replication and is not attenuated in the mice model |
| BAW_12006 | BAB1_2092 | bvrR | Two-component transcriptional regulator BvrR, important for virulence [9] |
| Genes with 3 binding sites | |||
| BAW_11853 | BAB1_1934 | ftsY | Cell division protein |
| BAW_12007 | BAB1_2093 | bvrS | Two-component histidine kinase BvrS, important for virulence [9] |
| Genes with 2 binding sites | |||
| BAW_20152 | BAB2_0156 | flgH | Flagellar basal body L-ring protein, important for virulence [62] |
| BAW_21057 | BAB2_1103 | motB | Flagellar motor protein MotB, important for virulence [62] |
| BAW_10069 | BAB1_0069 | btaE | Hyaluronate-binding autotransporter adhesin required for virulence, important for virulence [54] |
| BAW_10727 | BAB1_0756 | btpB | VirB type IV secreted effector, important for virulence [63] |
| BAW_20067 | BAB2_0067 | virB2 | Type IV secretion system protein VirB2, important for virulence [60] |
| BAW_20116 | BAB2_0118 | vjbR | LuxR family regulatory protein VjbR, important for virulence [64] |
| BAW_20365 | BAB2_0377 | eryG; rbsB-2 | Erythritol periplasmic binding protein, important for virulence [65] |
| BAW_20366 | BAB2_0378 | deoR | DeoR family regulatory protein, erythritol regulator [66] |
| BAW_20415 | BAB2_0432 | nikR | Nickel-responsive regulator of nikA, nikB, nikC, nickD and nikE |
| BAW_20417 | BAB2_0435 | nickB | Nickel transporter permease NikB |
| Genes with 1 binding site | |||
| BAW_10106 | BAB1_0108 | cgs | Cyclic beta 1–2 glucan synthetase, important for virulence [67] |
| BAW_10506 | BAB1_0525 | ppdK | Pyruvate phosphate dikinase, important for virulence [68] |
| BAW_20108 | BAB2_0109 | gnd | 6-phosphogluconate dehydrogenase, catalyzes the formation of D-ribulose 5-phosphate form 6-phospho-D-gluconate |
| BAW_11379 | BAB1_1445 | ftsA | Cell division protein FtsA. Is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring |
| BAW_11380 | BAB1_1446 | ftsQ | Cell division protein FtsQ |
| BAW_10696 | BAB1_0045 | tamA | Bacterial surface antigen (D15), important for virulence [17] |
| BAW_10045 | BAB1_0722 | omp25 | Outer membrane protein Omp25 precursor |
| BAW_11648 | BAB1_1725 | motA | Flagellar motor protein MotA, important for virulence [69] |
| BAW_11649 | BAB1_1726 | ND | COG1360 Flagellar Motor Protein |
| BAW_21059 | BAB2_1105 | fliF | Flagellar MS-ring protein, the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L; P; S; and M mounted on a central rod, important for virulence [62] |
| BAW_11312 | BAB1_1378 | ureC | Urease subunit alpha |
| BAW_11626 | BAB1_1703 | ftsH | ATP-dependent zinc metalloprotease |
| BAW_11630 | BAB1_1707 | omp16 | Pal = peptidoglycan-associated lipoprotein; also called omp16 |
| BAW_10046 | BAB1_0046 | tamB | Autotransporter translocation and assembly factor TamB This protein translocates adhesins and is essential for full virulence and intracelullar trafficking, important for virulence [70] |
| BAW_10686 | BAB1_0712 | bspB | Type IV secretion effector. This protein mediates inhibition of host secretion, important for virulence [71] |
| BAW_11394 | BAB1_1460 | mntH | Manganese transport protein MntH, important for virulence [72] |
| BAW_11577 | BAB1_1652 | vceA | VirB type IV secreted effector vceA, important for virulence [73] |
| BAW_20064 | BAB2_0064 | virB5 | Type IV secretion system protein VirB5, important for virulence [60] |
| BAW_20065 | BAB2_0065 | virB4 | Type IV secretion system protein VirB4, important for virulence [60] |
| BAW_12010 | BAB1_2096 | BAW_12010 | PTS system fructose subfamily transporter subunit IIA |
| BAW_12011 | BAB1_2097 | ptsH | Phosphocarrier HPr protein:histidine phosphorylation site in HPr protein |
| BAW_20348 | BAB2_0360 | mgtE | Divalent cation transporter/ magnesium transporter MtgE |
| BAW_20420 | BAB2_0438 | nikE | Nickel transporter ATP-binding protein NikE with NikABCD is involved with nickel transport into the cell |
| BAW_21102 | BAB2_1150 | bhuA | TonB-dependent receptor protein, important for chronic infection in mice [74] |
Purple: Cation metabolism related
Green: BvrR/BvrS-VjbR-VirB related
Blue: Cell cycle control, cell division, chromosome partitioning
Gold: Receptor binding related
Grey: Erythritol metabolism