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. 2022 Sep 21;17(9):e0274897. doi: 10.1371/journal.pone.0274897

Table 1. Top 20 hub genes with higher connectivity degree in the PPI network.

Gene sample Gene description Degree
LCK LCK proto-oncogene, Src family tyrosine kinase 52
SYK Spleen associated tyrosine kinase 50
CD4 CD4 molecule 47
PTPN6 Protein tyrosine phosphatase non-receptor type 6 46
LYN LYN proto-oncogene, Src family tyrosine kinase 42
CD247 CD247 molecule 38
PTPRC Protein tyrosine phosphatase receptor type C 36
HLA-DRA Major histocompatibility complex, class II, DR alpha 34
HLA-DRB1 Major histocompatibility complex, class II, DR beta 1 34
CD3G CD3g molecule 33
ZAP70 Zeta chain of T cell receptor associated protein kinase 70 33
CD8A CD8a molecule 32
CD3E CD3e molecule 31
CD3D CD3d molecule 31
VAV1 Vav guanine nucleotide exchange factor 1 31
CD28 CD28 molecule 29
PRKCQ Protein kinase C theta 29
LCP2 Lymphocyte cytosolic protein 2 28
CD80 CD80 molecule 27
HCK HCK proto-oncogene, Src family tyrosine kinase 27