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Cardiac index (CI) changes from baseline following single oral doses of riociguat (Rio) compared with inhaled nitric oxide (NO) in patients with chronic thromboembolic pulmonary hypertension (○) and pulmonary arterial hypertension (•). Horizontal lines indicate point estimates (least-squares means). Statistical significance was measured by the F statistic. *: p<0.05; **: p<0.01; ***: p<0.001; #: p<0.0001. Reproduced from [30] with permission from the publisher.
