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. Author manuscript; available in PMC: 2022 Sep 21.
Published in final edited form as: Sci Transl Med. 2022 Jul 6;14(652):eabj4310. doi: 10.1126/scitranslmed.abj4310

Fig. 6. Enhancing GAT-3 in thalamic astrocytes prevents astrogliosis-induced reduction in cortical sigma and gamma frequency power.

Fig. 6.

(A) Schematic of experimental timeline. Chronic wireless ECoG from S1 was obtained bilaterally in freely-behaving mice in their home cage for continuous one-week periods, up to seven weeks following induction of thalamic astrogliosis. (B) Representative plots of delta (1–4 Hz), sigma (12–15 Hz), gamma (30–75 Hz), and total band power (1–75 Hz), across weeks 1, 3, 5, and 7, obtained from a mouse with thalamic astrogliosis. Spectral analysis was performed on S1 ECoG in 1-hour bins. Horizontal lines indicate the average power of the frequency band during week one. (C) Average ECoG power for each mouse, seven weeks after thalamic astrogliosis induction, during the light (top) and dark cycle (bottom). Control: n=6 mice; Thalamic Astrogliosis: n=6 mice. (D) Average ECoG power for each mouse, seven weeks after thalamic astrogliosis induction and astrocytic GAT-3 enhancement. Control + GAT-3: n=3 mice; Thalamic Astrogliosis + GAT-3: n=4 mice. See table S9 for comparison of all frequency bands. Wilcoxon matched-pairs signed rank tests, *P<0.05.