Table 5.
NS5A Sequences at Sites Associated With Direct-Acting Antiviral (DAA) Resistance and Outcomes of DAA Treatment Regimens for Individuals Infected With Genotype 1l or Genotype 4r
| NS5A Position | Frequency | NS3/NS5A Rx | NS5A/NS5B Rx | NS3/NS5A/NS5B Rx | |||||
|---|---|---|---|---|---|---|---|---|---|
| 28 | 30 | 31 | NRx | NSVR | NRx | NSVR | NRx | NSVR | |
| gt1l | n = 6 | 1 | 1 | 7 | 0 | 2 | 2 | ||
| M | Q | M | n = 3 | 0 | 0 | 3 | 0 | 1 | 1 |
| M | R | M | n = 3 | 1 | 1 | 4 | 0 | 1 | 1 |
| gt4r | n = 12 | 2 | 2 | 9 | 4 | 4 | 3 | ||
| M | R | L | n = 6 | 1 | 1 | 4 | 2 | 2 | 2 |
| M | R | M | n = 1 | 0 | 0 | 2 | 0 | 0 | 0 |
| V | R | L | n = 2 | 0 | 0 | 2 | 1 | 1 | 0 |
| F | R | L | n = 1 | 0 | 0 | 1 | 1 | 0 | 0 |
| I | R | L | n = 1 | 0 | 0 | 0 | 0 | 1 | 1 |
| T | R | L | n = 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Underlined amino acids indicate possible resistance-associated variants.
Abbreviations: NRx, number receiving prescribed treatment; NSVR, number achieving sustained virological response; Rx, prescribed treatment.