Table 2.
Frequencies of APOE rs429358, rs7412, and MTHFR rs1801133 genotypes and alleles in hypertensive patients and controls.
| Genotype/allele | Hypertensive patients (n = 2,850) | Controls (n = 2,034) | χ 2 | P value | |
|---|---|---|---|---|---|
| APOE rs429358 | |||||
| T/T | 2320 (81.40%) | 1633 (80.29%) | 0.985 | 0.609 | |
| T/C | 506 (17.75%) | 382 (18.78%) | |||
| C/C | 24 (0.84%) | 19 (0.93%) | |||
| T | 5146 (90.28%) | 3648 (89.68%) | 0.968 | 0.338 | |
| C | 554 (9.72%) | 420 (10.32%) | |||
| HWE (χ2, P) | χ 2 = 0.389, P=0.533 | χ 2 = 0.412, P=0.521 | |||
|
| |||||
| APOE rs7412 | |||||
| C/C | 2464 (86.46%) | 1758 (86.43%) | 4.391 | 0.111 | |
| C/T | 365 (12.81%) | 270 (13.27%) | |||
| T/T | 21 (0.74%) | 6 (0.29%) | |||
| C | 5293 (92.86%) | 3786 (93.07%) | 0.157 | 0.718 | |
| T | 407 (7.14%) | 282 (6.93%) | |||
| HWE (χ2, P) | χ 2 = 3.340, P = 0.068 | χ 2 = 1.683, P=0.195 | |||
|
| |||||
| MTHFR rs1801133 | |||||
| C/C | 1573 (55.19%) | 1145 (56.29%) | 0.615 | 0.736 | |
| C/T | 1091 (38.28%) | 762 (37.46%) | |||
| T/T | 186 (6.53%) | 127 (6.24%) | |||
| C | 4237 (74.33%) | 3052 (75.02%) | 0.599 | 0.450 | |
| T | 1463 (25.67%) | 1016 (24.98%) | |||
| HWE (χ2, P) | χ 2 = 0.030, P=0.863 | χ 2 = 0.0002, P=0.988 | |||
HWE, Hardy Weinberg equilibrium.