Table 4.

Clinical characteristics of subjects stratified by MTHFR rs1801133 genotypes and alleles.

Clinical characteristics	C/C (n = 2,718)	C/T (n = 1,853)	T/T (n = 313)	P values	C allele (C/C + C/T) (n = 4,571)	T allele (C/T + T/T) (n = 2,166)	P values
Age, years	66.81 ± 12.38	66.66 ± 12.31	65.81 ± 12.40	0.394	66.75 ± 12.35	66.54 ± 12.32	0.505
Gender
Male, n(%)	1753 (64.50)	1193 (64.38)	214 (68.37)	0.377	2946 (64.45)	1407 (64.96)	0.703
Female, n(%)	965 (35.50)	660 (35.62)	99 (31.63)		1625 (35.55)	759 (35.04)
History of smoking, n(%)	752 (27.67)	520 (28.06)	89 (28.43)	0.933	1272 (27.83)	609 (28.12)	0.816
History of alcoholism, n(%)	170 (6.25)	119 (6.42)	20 (6.39)	0.977	289 (6.32)	139 (6.42)	0.915
SBP, mmHg	141.80 ± 27.63	141.73 ± 26.68	141.99 ± 23.52	0.987	141.77 ± 27.25	141.77 ± 26.25	0.999
DBP, mmHg	82.23 ± 15.69	82.83 ± 15.73	83.67 ± 14.62	0.190	82.48 ± 15.71	82.95 ± 15.57	0.243
Hcy, μmol/L	15.85 ± 6.59	16.76 ± 8.18	21.74 ± 13.71	<0.001	16.22 ± 7.29	17.48 ± 9.35	<0.001
TG, mmol/L	1.77 ± 1.85	1.76 ± 1.58	1.73 ± 1.51	0.904	1.77 ± 1.74	1.76 ± 1.57	0.781
TC, mmol/L	4.91 ± 1.44	4.84 ± 1.38	4.89 ± 1.30	0.301	4.88 ± 1.42	4.85 ± 1.37	0.366
HDL-C, mmol/L	1.27 ± 0.40	1.26 ± 0.39	1.26 ± 0.35	0.595	1.27 ± 0.40	1.26 ± 0.38	0.518
LDL-C, mmol/L	2.74 ± 0.99	2.71 ± 0.98	2.74 ± 0.95	0.536	2.72 ± 0.99	2.71 ± 0.97	0.609
Apo-A1, g/L	1.11 ± 0.34	1.10 ± 0.33	1.11 ± 0.29	0.719	1.10 ± 0.33	1.10 ± 0.33	0.819
Apo-B, g/L	0.85 ± 0.29	0.84 ± 0.29	0.86 ± 0.29	0.678	0.85 ± 0.29	0.85 ± 0.29	0.904