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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Immunol. 2022 Aug 3:ji2100870. doi: 10.4049/jimmunol.2100870

Fig. 3. The Notch ligand DL4 is critical for thymic development of CCR10+NK1.1+ ILC1s in adult but not newborn mice.

Fig. 3.

A-B) FC analysis of NK1.1+ ILCs and their expression of CCR10 in adult (A) and day0-3 old neonatal (B) DL4-WT (DL4f/f CCR10+/EGFP), DL4-KO (Foxn1CreDL4f/f CCR10+/EGFP) and Rag1−/−CCR10+/EGFP thymus. Average percentages and numbers of total CD3−NK1.1+ thymocytes and CCR10+NK1.1+ ILCs were shown in bar graphs. NK1.1+ ILC1s are gated from CD3−CD4−CD8− thymocytes. One dot represents one mouse. Results are of four independent experiments. ns = not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 as determined by two-tailed Student’s t test.