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. 2022 Sep 21;13:5440. doi: 10.1038/s41467-022-33068-4

Fig. 4. Inhibition of SARS-CoV-2 viral replication by HLA-A24-restricted T-cell lines from vaccinated donors.

Fig. 4

a Viral replication of the prototype in the presence of NF9- or QI9-specific T cells from GV36, or without T cells. b, c Inhibition of viral replication by NF9-specific T cells (b) and QI9-specific T cells (c) compared to without T cells in three vaccinated donors are shown. a A statistically significant difference versus without T cells (**p < 0.01) was determined by an unpaired two-tailed Student’s t test (p = 0.009 and p = 0.0036 versus without NF9 and QI9-specific T cells, respectively. Data are expressed as mean ± SD. b, c A statistically significant difference versus Omicron BA.1 (**p < 0.01) was determined by a two-tailed Mann–Whitney test and p = 0.0043, 0.0043, and 0.002 versus prototype, Omicron BA.2 and Delta, respectively. ns, no statistical significance. Data are expressed as median. a–c Assay was performed in triplicate or quadruplicate and data are representative of two independent experiments. Source data are provided as a Source Data file.