Fig. 4. Conservation of impacts of orthologues of Clinvar variants.

Each plot shows the consequence of variants in humans (on the left) and the consequence of variants found at the same position in the pig or cattle genome on the right. The ribbons connect sets of variants, with the width of each ribbon indicating the number of variant pairs with the given combination of consequences across the two species. Ribbons in blue indicate where variants have potentially conserved impacts on the protein across species. a The conservation of impact of genic orthologous variants across human and cattle where variants show the same allele change. b The same as (a) but for human-pig orthologous variants. c Conservation of impact of variants across human and cattle where their locations are orthologous but they show different allele changes. d The same as (c) but for human-pig orthologous variants. The data underlying this figure can be found in Supplementary Data 3.