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. 2022 Sep 21;13:5422. doi: 10.1038/s41467-022-32985-8

Fig. 2. Magnitude of anti-SARS-CoV-2 adaptive immune responses measured in venous blood samples up to six months preceding a positive COVID-19 test.

Fig. 2

Venous blood samples obtained from healthy donors (n = 148) were assessed for the magnitude of SARS-CoV-2-specific IFN-γ+ T cell responses (a; ****P < 0.0001) and SARS-CoV-2-specific IgG-binding responses targeting spike receptor binding domain (‘RBD’) (b), spike subunit 1 (‘S1’) (c), spike subunit 2 (‘S2’) (d) and nucleocapsid (‘N’) (e; **P = 0.0084). Participants self-reporting a COVID-19 positive test (PCR and/or lateral flow test) are highlighted; all cases of infection occurred within 6 months of blood draw. Comparisons used two-sided Mann–Whitney tests. Data are presented as box plots (centre line at the median, upper bound at 75th percentile, lower bound at 25th percentile) with whiskers at minimum and maximum values. Each dot represents one donor. ns not significant. f Heat map demonstrating Spearman’s rank correlations between specified dataset variables. Comparisons that were not statistically significant were excluded from the matrix and are represented by empty boxes. Source data are provided as a Source Data file.