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. 2022 Sep 21;13:5308. doi: 10.1038/s41467-022-32944-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Input/output relationship plots of hippocampal slices from 2 N and Ts2 mice treated with either vehicle or NFMD (n = 4 mice for Ts2 group and n = 5 mice for the other treatment groups), and graphed using GraphPad Prism8.0.1 [no significant difference between the slopes, Linear regression F (3, 40) = 0.107, p = 0.956]. b Plots of LTP in the Schaffer collateral synapses (CA3-CA1) induced by theta-burst stimulation (TBS) of mice from four treatment groups [Linear regression for, significant difference between the slopes of 2 N vs Ts2, F(1, 236) = 6.925, p = 0.0091; no significant difference between the slopes of Ts2 vs Ts2-NFMD, F(1, 236) = 2.103, p = 0.148]. c Averages of fEPSP slopes at 1, 50, and 110 min following tetanic stimulation; NFMD treatment increased the fEPSP slope of Ts2 mice by 18% at the 110 min time point [Ordinary One-Way ANOVA with Tukey correction, at 1 min time point, F(3, 34) = 20.75, R square = 0.647, for 2 N vs Ts2, p < 0.0001, 95% CI = 54.62, 139.5; at 50 min time point, F(3, 34) = 16.44, R square = 0.592, for 2 N vs Ts2, p < 0.0001, 95% CI = 49.54, 144.5; at 110 min time point, F(3, 34) = 19.00, R square = 0.626, for 2 N vs Ts2, p < 0.0001, 95% CI = 72.09, 139.6, for Ts2 vs Ts2-NFMD, p = 0.0334, 95% CI = −67.71, −2.938]. d Novel Object Recognition (NOR) test at 24 h after familiarization session, represented by recognition index in 2 N (n = 8) and Ts2 (n = 8) mice before (Pre) and after (Post) 4 weeks of NFMD treatments [Ordinary One-Way ANOVA with Tukey correction, F(3, 24) = 1.967, R square = 0.197, for Ts2-pre vs Ts2-post, p = 0.0262, 95% CI = 2.406, 34.97]. e Open field test results including speed, distance and percentage of time spent in thigmotaxis for 2 N (n = 8) and Ts2 mice (n = 8) Pre and Post 4 weeks of NFMD treatment [Ordinary One-Way ANOVA with Tukey correction, For Speed F(3, 22) = 5.936, R square = 0.447, for 2N-NFMD-pre vs Ts2-NFMD-pre, p = 0.0148, 95% CI = −36.97, −4.47; for Ts2-NFMD-pre vs Ts2-NFMD-post p = 0.0148, 95% CI = 3.572, 34.89; For Distance F(3, 22) = 9.784, R square = 0.572, for 2N-NFMD-pre vs Ts2-NFMD-pre, p = 0.0434, 95% CI = −27.75, −0.295; for Ts2-NFMD-pre vs Ts2-NFMD-post p = 0.0003, 95% CI = 9.205, 32.77). Data are presented as mean values ± SEM. Statistical significance represented by asterisks *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. Source data are provided as a Source Data File.